P-Shot for Stamina, Sensation, and Sexual Performance—Treating Erectile Dysfunction with Plasma

Posted by Medical Board on September 2, 2021 in Uncategorized Last updated on September 2, 2021

Currently about 10% of men aged 40-70 struggle with the inability to maintain an erection firm enough for sex.(1)

Physical Causes

There are many reasons a man may have erectile dysfunction serious enough to hamper his ability to engage in sexual intercourse.  Physical conditions such as prostate disease, high blood pressure, diabetes, high cholesterol, and cardiovascular disease may interfere with healthy erectile function.  Certain medications may also cause ED, as well as hormonal changes, and the natural course of aging.

Psychological Causes

Anxiety, stress, and depression can all contribute to erectile dysfunction.  Unresolved conflicts within the relationship can lead to sexual dysfunction as well.(3)

What Is The Priapus Shot?

The Priapus shot or P-Shot is a revolutionary new treatment for erectile dysfunction in men.  The shot involves injecting platelet-rich plasma (PRP) from the patient, directly into the penis, where the body’s own cells help grow tissue and promote blood flow.  Patients who undergo P-Shot treatment experience better sexual performance, greater stamina, increased sensation, and in many cases an increase in length and girth. 

PRP therapy is viable for many conditions and situations including:

  • Erectile dysfunction
  • Lichen sclerosus
  • Peyronie’s disease
  • Penis enhancement
  • Sexual function, enhanced orgasm and sexual performance

What Is Platelet-Rich Plasma?

Platelet-rich plasma facilitates the wound healing process and supports the body’s natural blood clotting mechanism.

Regenerative medicine involves the body’s own ability to naturally heal itself.  Plasma is the liquid part of blood that carries platelets or blood cells necessary for growth and healing processes in the body.(6)

Growth factors are needed in wound healing, chemotaxis (cell movement), cell proliferation, cell differentiation and angiogenesis (development of new blood vessels).

How Platelet-Rich Plasma Works

When platelets are activated, many types of growth differentiation factors get released.  Some of these help to facilitate nerve repair and regenerate tissue.  When erectile dysfunction is caused by atrophy of smooth muscle this can lead to corporo-venous occlusive erectile dysfunction even if arterial flow is normal.(8)

Some patients with erectile dysfunction have low-grade systemic inflammation due to metabolic syndrome.(2)

Emerging platelet derived therapies that address inflammation and promote cellular nerve and tissue regeneration are found to be useful in treating patients.(8)

How Does The P-Shot Work?

The P-Shot utilizes platelet-rich plasma therapy.  This has traditionally been used for patients who are recovering from muscle and joint injuries, as well as for the treatment of other chronic health conditions.

The P-Shot may work by allowing increased blood flow to the penis and by repairing tissue or cells.  New neural pathways may also be created by reinforced positive experience.

Are There Side Effects To The P-Shot?

Most men tolerate the P-Shot very well and only experience mild side effects if any.

Mild effects of the P-Shot include swelling, redness, and bruising at the site of the injection.  These may only last four to six days, however.

Rare complications can occur including infection, scarring, and cold sore outbreaks (if there is a history of the herpes simplex virus).

What To Expect During My P-Shot Procedure

  1. P-Shot treatment will take place at a doctor’s office, outpatient clinic or treatment center.  There, a physician specifically certified to perform P-Shot therapy will apply a numbing ointment to the genital area. 
  • The physician will then take a small blood sample from the arm.
  • The blood will be placed into a centrifuge to separate and isolate the platelet-rich plasma (PRP).
  • The PRP is injected into the penis in 4 or 5 separate injections.
  • A penis pump will be provided for the patient to take home.  The patient will be instructed to use it for 10 minutes per day over a period of a few weeks.  This will help facilitate blood draw into the penis to ensure the P-Shot is working.

How Soon Does The P-Shot Take Effect?

Some patients respond within 24 hours and get long lasting results with only a single treatment.  Typically however, most patients will need three to six treatments over the course of a few months.  The peak of optimal response will occur after about two months.

How Will I Feel After My Appointment?

You may experience mild discomfort or bruising around the injection site, but should be able to resume normal activity the next day.  Most doctors recommend abstaining from sexual intercourse for a few days and refraining from any heavy lifting or intense physical exercise directly following the procedure.

Is P-Shot The Only Option For ED?

There are several therapies used to treat erectile dysfunction in men depending on the seriousness and frequency of ED symptoms.

Non-invasive First line treatments include:

  • Lifestyle changes
  • Oral medications
  • Vacuum erectile devices
  • Intraurethral suppositories
  • Invasive Treatments include:
  • Shockwave therapy
  • External prosthetic devices
  • Platelet-rich plasma injections(4)

How Well Does Platelet-Rich Plasma Therapy Work?

In 6 month, double-blind, randomized, placebo-controlled clinical trials, 69% of patients treated with PRP injections for erectile dysfunction saw significant improvement for ED compared to only 27% in the placebo group.(7)

How Safe Are PRP Injections?

Injections of platelet-rich plasma are not new and have been used for many years for angiogenesis (blood vessel development) and wound healing.  PRP has been safely and effectively used to treat a number of urological conditions including erectile dysfunction, Peyronie’s disease and stress urinary incontinence (SUI).  Its therapeutic use for P-Shot application is well founded.


1Boston University MEDICAL CAMPUSSEXUAL MEDICINE. Sexual Medicine RSS. (n.d.). https://www.bumc.bu.edu/sexualmedicine/physicianinformation/epidemiology-of-ed/. 

2C;, V. C. R. K. I. N. S. (n.d.). Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: Common links. European urology. https://pubmed.ncbi.nlm.nih.gov/17707576/. 

3Healthdirect Australia. (n.d.). Erectile dysfunction. healthdirect. https://www.healthdirect.gov.au/erectile-dysfunction. 

4Krzastek, S. C., Bopp, J., Smith, R. P., & Kovac, J. R. (2019, January 25). Recent advances in the understanding and management of erectile dysfunction. F1000Research. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348436/. 

5Matz, E. L., Pearlman, A. M., & Terlecki, R. P. (2018, January). Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions. Investigative and clinical urology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754585/. 

6Platelet-Rich plasma (prp) INJECTION: How it WORKS: HSS. Hospital for Special Surgery. (n.d.). https://www.hss.edu/condition-list_prp-injections.asp. 

7Poulios E;Mykoniatis I;Pyrgidis N;Zilotis F;Kapoteli P;Kotsiris D;Kalyvianakis D;Hatzichristou D; (n.d.). Platelet-Rich plasma (PRP) Improves erectile function: A double-blind, randomized, placebo-controlled clinical trial. The journal of sexual medicine. https://pubmed.ncbi.nlm.nih.gov/33906807/. 

8Safety and efficacy of autologous platelet-rich plasma for erectile dysfunction. – full text view. Full Text View – ClinicalTrials.gov. (n.d.). https://clinicaltrials.gov/ct2/show/NCT04396795. 

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